题目：From Biomaterials and Stem Cells to Regenerative Medicine: A Bioengineering Perspective

报告人：Xuejun Wen
　　　　Associate Professor， Department of Bioengineering, Clemson University, and the Departments of Cell Biology & Anatomy, Orthopaedic Surgery, Neuroscience, Dental Medicine, and Hollings Cancer Center at the Medical University of South Carolina.

时间：2008年5月16日(周五)上午9:30

地点：闵行校区材料楼A楼308会议室

摘要

　　My research program is aimed at developing clinically applicable strategies for tissue and organ regeneration based upon tissue engineering and regenerative medicine principles to enhance human health. The specific areas of my research cover novel biopolymer syntheses/nanostructured biomaterials development, scaffold design and fabrication, stem cell biology and engineering, tissue engineering and regenerative medicine, in vitro and in vivo models for translational research, and proteomics, genomics, biosensors, and biomedical imaging. Recent progresses in my lab in all these areas will be discussed. Examples of using bioengineering approaches for the central nervous system (CNS) repair (e.g., spinal cord injury, Parkinson’s disease, traumatic brain injury, and brain stroke), sensory protection and functional restoration (hearing loss), cardiovascular diseases (heart infarction), lung tissue regeneration, and orthopedic tissue regeneration will be discussed. Finally, the novel concept of in vivo tissue engineering based upon the manipulation of endogenous stem cells that are resident in the tissues for cell replacement and tissue regeneration will be introduced.

　　Biosketch

　　Xuejun Wen, M.D., Ph.D., holds tenured Associate Professor positions in the Department of Bioengineering, Clemson University, and the Departments of Cell Biology & Anatomy, Orthopaedic Surgery, Neuroscience, Dental Medicine, and Hollings Cancer Center at the Medical University of South Carolina. Dr. Wen obtained his Ph.D. degree in Bioenginering with emphasis on Tissue Engineering in 2003 from the University of Utah in Salt Lake City. He possesses a diverse background combining materials science and engineering, medicine, cell and molecular biology, cellular and tissue engineering, neuroscience, and stem cell biology. In particular, he has unique expertise dedicated to tissue-engineered biomedical device design and functional optimization adaptable for a variety of therapeutic interventions. By engineering non-degradable, biodegradable, and biological interactive materials with cells or tissue, Dr. Wen has successfully designed, constructed, and tailored the properties of neural bridging devices, cell-encapsulating devices, drug delivery vehicles, nano-scale and micron-scale drug carriers, intraocular and inner ear long-term delivery devices, and middle ear ventilation devices that have demonstrated clinical potential of treating a wide range of diseases. His major strengths in research reside in the areas of biomaterial development, scaffold and bioreactor design, multiple tissue/organ regenerations, and stem cell biology and engineering.